GENOS FIBROCELL PREMIUM
Natural fibroblast stimulation & telomere extension medical cell rejuvenation from the inside
GENOS FIBROCELL PREMIUM as an approved magistral prescription (following the German medicine act, § 21/2 AMG) is a natural beauty source enriched with RM31 and is used by medical practitioners to e.g. counteract the skin aging process. Using the innovative and patented GENOS method, highly active fibroblasts can naturally be generated which leads the skin to be supported in its regeneration and renewal from within.
As result, a greater amount of collagen, which is crucial for skin firmness, is produced and more moisture can be stored in the skin. Wrinkles and sagging skin can thus be reduced in a natural way. By lengthening the telomeres, the metabolic processes caused by aging and diminished are reactivated, so that overall improved cell function and organ function is possible. Fibroblasts are useful also for other medical issues: also improving wound healing and healing of the skin.
WHY FIBROBLASTS ARE SO IMPORTANT?
Fibroblasts are cells that are a major component of connective tissue. They play an important role in the synthesis of the intercellular substance needed to build the so-called extracellular matrix. Fibroblasts belong to the fixed connective tissue cells. After maturation into fibrocytes, they become immobile. Fibrocytes and fibroblasts are the same cell type with different activity status. Fibroblasts are responsible for the firmness and density of the skin. They have the ability to produce the important support molecules collagen and elastin, which are responsible for the skin‘s resistance and elasticity. Collagen is a protein produced by the body, which enables the skin to absorb and retain moisture. Over the years, the activity of fibroblasts decreases, causing the skin to show the typical aging effects and the connective tissue to change. It becomes flabbier and the support and stability functions diminish. Likewise, the skin‘s ability to retain moisture decreases, making it drier and more prone to wrinkles.
THE GENOS PROCEDURE
Cell rejuvenation through signal transduction
The GENOS procedure has been developed over the last 20 years from interdisciplinary fields of biophysics, biochemistry, epigenetics, microbiology, toxicology and regenerative medicine and has been patented for Europe and the USA. It is currently the only method of its kind that uses biophysical stimulation to transfer specific molecules into signals, which can be harnessed for intranuclear regulation of key epigenetic positions as well as other cellular functions by using signal transduction.
In biochemistry and physiology, signal transduction refers to a process in which an extracellular signal is mediated across the cell membrane into the cell interior. The process consists of several steps in which second messengers, receptors and other enzymes can be involved. The GENOS method enables for the first time an intranuclear access by signal transduction of the biophysically activated molecule 31 (RM31®) and use it for cell regeneration.
RM31 Regulation Molecule
The key molecule that enables cell rejuvenation
RM31 is the name of a natural molecule that occurs in the human body and is involved in many cellular mechanisms. Its application is therefore multiple. RM31 reacts endo-genously and is therefore without known side effects. It is highly effectively activated by the GENOS process and subsequently released in the body in a targeted manner. The release leads to a cell regulation. This causes an increase in fibroblasts as well as an extension of telomeres. In vivo studies show a cell rejuvenation of up to 5 years within 3-4 weeks.
PDL per Treatment - week 1
PDL per Treatment - week 2
PDL per Treatment - week 3
Shortening Rate
Already after 10 min of treatment of fibroblasts with the GENOS method (signal of RM31) there is a significant increase in the amount of fibro-blasts. Analogous after 24 h. The graph shows that after 3 weeks the fibroblasts remain stable compared to the non-treated sample and continue to show a higher quantity.
Telomere shortening occurs with each cell division. It shows that telomere shortening in fibroblast treated with the GENOS method (RM31 signal) is 180 base pairs (bp) less than in non-treated.
Competitive advantage over the competition
Figure 1 clearly shows the enormous advantage of FIBROCELL BOOST compared to another leading competitor product: After only 3 weeks there is an extension of telomeres by o.6 kilobase pairs (kb), while the competitor product achieves a telomere extension of only 0.35 kb after a period of 3 months.
TELOMERE
Proven effect of GENOS Fibrocell Telomerlength measurement
The length of the telomeres determines the biological age of a human being. They are found at the ends of chromosomes and function as a protective caps to prevent the degradation of the genetic material. Telomeres shorten after each cell division to preserve the remaining DNA containing genes. This protects the DNA from any damage. This occurs until the telomere length reaches a critical shortening point after which cell division can no longer take place, thereby causing the cell death. This process causes the aging of the cell and the aging of the human being.
How can our telomeres help us understand
the relationship between biological age and chronological age?
Not everyone ages at the same rate, regardless of whether their chronological age is the same. Therefore, it is important to identify molecular markers that can be used to estimate the aging level of an organism. Telomeric length is one of the most well studied and reliable markers of molecular-level aging known to the scientific community. Studying telomeres is very useful, both for health professionals and individuals, in order to predict the premature development of certain aging diseases and to try to reduce the risk of suffering them. Biological age is a snapshot of your organism's age. Lifestyle improvements can reduce the rate of telomere shortening, and thus slow down the molecular aging process.
Why are telomeres so important?
Telomere length is considered an excellent biomarker of cellular regenerative capacity and, therefore, of the aging of organisms. Each cycle of cellular division leads to a progressive telomeric attrition resulting in telomere length shortening with increasing age.
Telomeres are found at the ends of chromosomes and function as a protective caps to prevent the degradation of the genetic material. Telomeres shorten after each cell division to preserve the remaining DNA containing genes. This occurs until the telomere length reaches a critical shortening point after which cell division can no longer take place, thereby causing the cell to enter into a state of senescence and/or cell death.
This image shows the telomers and their ends and on the right side the nuclei of some cells (in blue) contained in a blood sample, with their telomeres high-lighted as pink dots. A greater intensity of fluorescence in the pink dots indicates longer telomere length and a lower percentage of short telomeres.
(source: Life Length Madrid)